KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR2A
All Species:
26.06
Human Site:
S254
Identified Species:
38.22
UniProt:
P13861
Number Species:
15
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13861
NP_004148.1
404
45518
S254
K
K
R
K
M
F
E
S
F
I
E
S
V
P
L
Chimpanzee
Pan troglodytes
XP_001148361
477
52826
S328
K
K
R
K
M
Y
E
S
F
I
E
S
L
P
F
Rhesus Macaque
Macaca mulatta
XP_001089109
461
51060
S312
K
K
R
K
M
Y
E
S
F
I
E
S
L
P
F
Dog
Lupus familis
XP_541890
401
45078
S251
K
K
R
R
M
F
E
S
F
I
E
S
V
P
L
Cat
Felis silvestris
Mouse
Mus musculus
P12367
401
45371
S251
K
K
R
K
M
F
E
S
F
I
E
S
V
P
L
Rat
Rattus norvegicus
P12368
401
45522
S251
K
K
R
K
M
F
E
S
F
I
E
S
V
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509189
323
36258
V194
V
S
E
R
L
K
V
V
D
V
I
G
T
K
I
Chicken
Gallus gallus
Q5ZM91
382
43332
E249
R
K
R
K
M
Y
E
E
F
L
S
K
V
S
I
Frog
Xenopus laevis
NP_001084637
402
45172
N253
K
K
R
R
L
Y
E
N
F
I
E
S
L
P
F
Zebra Danio
Brachydanio rerio
NP_001070838
397
44672
C251
K
K
R
R
M
Y
E
C
F
I
E
S
I
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P81900
377
42730
E235
R
K
R
K
M
Y
E
E
L
L
N
S
V
P
M
Honey Bee
Apis mellifera
XP_392905
383
43849
D241
K
K
R
K
M
Y
E
D
L
I
N
K
V
P
M
Nematode Worm
Caenorhab. elegans
P30625
366
41449
E233
K
K
R
K
M
Y
D
E
F
L
S
K
V
Q
I
Sea Urchin
Strong. purpuratus
Q26619
369
41770
E232
K
K
R
R
I
Y
E
E
L
L
E
K
V
S
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
W271
A
T
S
D
C
L
L
W
A
L
D
R
L
T
F
Red Bread Mold
Neurospora crassa
Q01386
385
42138
S254
S
R
R
R
M
Y
E
S
F
L
E
E
V
P
I
Conservation
Percent
Protein Identity:
100
58.4
61.1
91
N.A.
86.8
86.8
N.A.
58.6
35.1
64.8
71.2
N.A.
48.7
49.7
32.9
52.2
Protein Similarity:
100
68.3
70.7
94.5
N.A.
91.3
92
N.A.
69
52.7
80.6
83.6
N.A.
67.8
69
54.9
69
P-Site Identity:
100
80
80
93.3
N.A.
100
100
N.A.
0
46.6
60
73.3
N.A.
53.3
60
46.6
40
P-Site Similarity:
100
93.3
93.3
100
N.A.
100
100
N.A.
26.6
73.3
93.3
93.3
N.A.
80
73.3
73.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
37.2
35.4
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
55.2
51.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
86.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
7
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
7
0
0
7
7
7
0
7
0
0
0
0
% D
% Glu:
0
0
7
0
0
0
82
25
0
0
63
7
0
0
0
% E
% Phe:
0
0
0
0
0
25
0
0
69
0
0
0
0
0
25
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
0
0
57
7
0
7
0
32
% I
% Lys:
69
82
0
57
0
7
0
0
0
0
0
25
0
7
0
% K
% Leu:
0
0
0
0
13
7
7
0
19
38
0
0
25
0
32
% L
% Met:
0
0
0
0
75
0
0
0
0
0
0
0
0
0
13
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
13
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
69
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% Q
% Arg:
13
7
88
38
0
0
0
0
0
0
0
7
0
0
0
% R
% Ser:
7
7
7
0
0
0
0
44
0
0
13
57
0
13
0
% S
% Thr:
0
7
0
0
0
0
0
0
0
0
0
0
7
7
0
% T
% Val:
7
0
0
0
0
0
7
7
0
7
0
0
63
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
63
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _